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Drug-Like Properties: Concepts, Structure Design and Methods from ADME to Toxicity Optimization by Li Di, Edward H Kerns

• Drug-Like Properties: Concepts, Structure Design and Methods from ADME to Toxicity Optimization
• Li Di, Edward H Kerns
• Page: 580
• Format: pdf, ePub, mobi, fb2
• ISBN: 9780128010761
• Publisher: Elsevier Science

Drug-Like Properties: Concepts, Structure Design and Methods from ADME to Toxicity Optimization

Download free Drug-Like Properties: Concepts, Structure Design and Methods from ADME to Toxicity Optimization by Li Di, Edward H Kerns English version

Of the thousands of novel compounds that a drug discovery project team invents and that bind to the therapeutic target, only a fraction have sufficient ADME (absorption, distribution, metabolism, elimination) properties, and acceptable toxicology properties, to become a drug product that will successfully complete human Phase I clinical trials. Drug-Like Properties: Concepts, Structure Design and Methods from ADME to Toxicity Optimization, Second Edition, provides scientists and students the background and tools to understand, discover, and develop optimal clinical candidates. This valuable resource explores physiochemical properties, including solubility and permeability, before exploring how compounds are absorbed, distributed, and metabolized safely and stably. Review chapters provide context and underscore the importance of key concepts such as pharmacokinetics, toxicity, the blood-brain barrier, diagnosing drug limitations, prodrugs, and formulation. Building on those foundations, this thoroughly updated revision covers a wide variety of current methods for the screening (high throughput), diagnosis (medium throughput) and in-depth (low throughput) analysis of drug properties for process and product improvement. From conducting key assays for interpretation and structural analysis, the reader learns to implement modification methods and improve each ADME property. Through valuable case studies, structure-property relationship descriptions, and structure modification strategies, Drug-Like Properties, Second Edition, offers tools and methods for ADME/Tox scientists through all aspects of drug research, discovery, design, development, and optimization. Provides a comprehensive and valuable working handbook for scientists and students in medicinal chemistry Includes expanded coverage of pharmacokinetics fundamentals and effects Contains updates throughout, including the authors’ recent work in the importance of solubility in drug development; new and currently used property methods, with a reduction of seldom-used methods; and exploration of computational modeling methods

A Pharmacology Primer, Fourth Edition: Techniques for More
Drug-like Properties: Concepts, Structure Design and Methods: from ADME to Structure Design and Methods: from ADME to Toxicity Optimization by Li Di  Drug-like Properties: Concepts, Structure Design and Methods, 1st
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Drug-Like Properties: Concepts, Structure Design and Methods: From ADME to Toxicity Optimization by Edward H Kerns, Li Di, ISBN 9780123695208. A Novel Relay Method for Determining Low-Clearance Values
A novel relay method has been developed using cryopreserved human 2011) ( too long a half-life, complex dosing regimen, toxicity due to accumulation, and concerns on metabolic stability during lead optimization and candidate selection. (2008) Drug-like Properties: Concepts, Structure Design and Methods: from  Drug-like Properties: Concepts, Structure Design and Methods: from
Drug-like Properties: Concepts, Structure Design and Methods: from ADME to Toxicity Optimization eBook: Li Di, Edward H Kerns: Amazon.fr: Boutique Kindle. Pharmacokinetics, Metabolism, and in Vivo Efficacy of the
Lead optimization requires identification of biochemical and The lack of mouse toxicity (in either the PK study or the in vivo efficacy study) [PubMed]; Kerns E.; Di L.Drug-Like Properties: Concepts, Structure Design and Methods: from ADME to Toxicity Optimization; Academic Press: New York, 2008. Drug-like Properties: Concepts, Structure Design and Methods
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Drug-like Properties: Optimizing Pharmacokinetics and Safety in Drug and toxicity and proven approaches to optimize compounds for drug discovery structure modification strategies, SAR, and lead selection and optimization. He is co-author of the book Drug-Like Properties: Concepts, Structure Design and Methods,  Drug-Like Properties Concepts, Structure Design and Methods
Drug-Like Properties Concepts, Structure Design and Methods - From ADME to Toxicity Optimization. Book in english language. Di, Li.

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